5. Lupus nephritis, wire loop lesion - Micro, High Power
The glomeruli are generally the major target of damage in lupus nephritis, though interstitial and tubular changes are also frequent (20-50% of patients). Note the thickened, hyalinized loops of capillaries. In this case, is there a global or more segmental involvement of the glomerulus? Answer
What accounts for this thickening? Answer

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