6. Lupus nephritis - Micro, High Power
The spectrum of histopathologic changes in lupus nephritis is
extremely wide, and this is complicated by the fact that many changes
are sequential and often not synchronized in all glomeruli. In
progressive disease, the end result is the destruction of glomeruli.
Here we see elements of early destruction. Fibrinoid necrosis is
marked by loss of nuclei, loss of normal glomerular constituents, and
the presence of scattered PMNs and karyorrhectic debris. What is the
significance of antinuclear antibodies (ANA) tests in this patient?
Answer
